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ea0099p347 | Pituitary and Neuroendocrinology | ECE2024

Safety profile of growth hormone replacement (GHr) in GH deficient patients during transition period treated for intracranial tumors and malignancy in childhood- Single center expirence

Doknic Mirjana , Curcic Mihajlo , Stojanovic Marko , Milenkovic Tatjana , Zdravkovic Vera , Jesic Maja , Todorović Slađana , Milicevic Mihailo , Stanimirovic Aleksandar , Scepanovic Vuk , Mitrović Katarina , Vukovic Rade , Miljic Dragana , Pekic Djurdjevic Sandra , Cekic Ivana , Jevtic Ivan , Manojlovic Gacic Emilija , Grujicic Danica , Petakov Milan , Soldatovic Ivan

Introduction: Considering the mitogenic potential of GH and IGF1, the safety profile of growth hormone therapy since the beginning of its use has been debated. From that point of view, adolescents in transition to adulthood who were treated in childhood for endocranial tumors or malignancies require special caution.Patients and Methods: In a monocentric, observational, retrospective cross-sectional study spanning 18 years, we analyzed 251 childhood onset...

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Safety profile of growth hormone replacement (GHr) in GH deficient patients during transition period treated for intracranial tumors and malignancy in childhood- Single center expirence

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